Diabetes in NOD Mice

NOD mice spontaneously develop diabetes, and so provide a polygenic model for type 1 diabetes in human patients.

The first clinical sign of disease is increased blood glucose concentration; this is normally detectable at between 12 and 30 weeks of age. The early stage disease is characterized by insulitis, an inflammation of the islets of Langerhans in the pancreas. Lymphocyte infiltration of the islets is histologically detectable several weeks before diabetes onset and results in destruction of beta cells (insulin-producing cells) in the islets. Because beta cells produce insulin, their destruction results in insulin deficiency and high blood glucose.

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